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- DOI 10.18231/j.idjsr.2025.019
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CrossMark
Non-surgical management of periodontal disease exacerbated by herpes virus: A case report
- Author Details:
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Zubeida Haleem *
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Shivanand Aspalli
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Nagappa Guttiganur
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Narayana Geethika
Zubeida Haleem *
Periodontal disease is a chronic inflammatory condition affecting the supporting structures of the teeth, primarily driven by bacterial pathogens and host immune responses. However, recent evidence suggests that viral infections, particularly Herpes Simplex Virus (HSV), may play a significant role in the pathogenesis and progression of periodontal disease. HSV, a neurotropic virus with lifelong latency, is known to modulate immune responses and contribute to tissue destruction in various oral conditions.
HSV-1, the predominant strain affecting the oral cavity, has been detected in periodontal pockets and is associated with increased inflammation, immune dysregulation, and enhanced bacterial virulence. The virus is thought to exacerbate periodontal disease through mechanisms such as cytokine upregulation, apoptosis of host cells, and interactions with periodontal pathogens. Furthermore, HSV has been linked to aggressive and necrotizing periodontal diseases, particularly in immunocompromised individuals.
Understanding the relationship between HSV and periodontal disease is crucial for improving treatment strategies. Investigating viral contributions to periodontal pathology may open new avenues for targeted antiviral therapies alongside conventional periodontal treatment. This case report highlights the relationship between HSV and periodontitis, emphasizing the importance of non-surgical management approaches in treating periodontal conditions exacerbated by the virus.
Keywords: Herpes simplex virus, Periodontal diseases, Gingival enlargement
References
- Slots J. Periodontal herpesviruses: prevalence, pathogenicity, systemic risk. Periodontol 2000. 2021;87(1):157–67.
- Mattila K, Ainamo J, Asikainen S. Herpesviruses and periodontitis: a systematic review. J Clin Periodontol. 2023;50(2):198–210.
- Varghese S. Role of herpes virus in periodontal diseases. IOSR J Dent Med Sci. 2014;13:71–3.
- Contreras A, Zadeh HH, Nowzari H. Herpesviruses in periodontal disease: a review. J Periodontol. 2022;93(5):687–96.
- Zhang Y, Lo K, Wang C. Herpes simplex virus-induced upregulation of inflammatory cytokines in human gingival fibroblasts. Virol J. 2024;21(1):323.
- Górska R, Nowakowska Z. The impact of periodontal disease on herpes simplex virus reactivation. Oral Dis. 2020;26(1):56–61.
- Botero JE, Contreras A, Lafaurie GI. Viral-bacterial interactions in periodontitis: a potential role for herpesviruses? Clin Oral Investig. 2021;25(3):981–91.
- Herrera D, Sanz M, Jepsen S, Needleman I, Roldán S. Non-surgical periodontal treatment for drug-influenced gingival enlargement: A 4-year follow-up case report. Int J Odontostomatol. 2021;15(2):184–90.
- Ardila CM, Bedoya-García JA. Systemic and clinical treatment of gingival hyperplasia associated with anticonvulsant drugs: A case 106 Haleem et al. / International Dental Journal of Student's Research 2025;13(2):102-106 report. Rev Clin Periodoncia Implantol Rehabil Oral. 2019;12(1):50–5.
- Abramson JS, Wheeler JG. Virus-induced neutrophil dysfunction: role in the pathogenesis of bacterial infections. Pediatr Infect Dis J. 1994;13(7):643–52.
- Hanookai D, Nowzari H, Contreras A, Morrison JL, Slots J. Herpesviruses and Periodontopathic Bacteria in Trisomy 21 Periodontitis. J Periodontol. 2000;71(3):376–84
- Cardoso CR, Garlet GP, Moreira AP, Junior WM, Rossi MA, Silva JS. Characterization of CD4+CD25+ natural regulatory T cells in the inflammatory infiltrate of human chronic periodontitis. J Leukoc Biol. 2008;84(1):311–8.
- Mendez JC, Dockrell DH, Espy MJ, Smith TF, Wilson JA, Harmsen WS. Human beta-herpesvirus interactions in solid organ transplant recipients. J Infect Dis. 2001;183(2):179–84.
- Feldstein AE, Razonable RR, Boyce TG, Freese DK, El-Youssef M, Perrault J, Prevalence and clinical significance of human herpesviruses 6 and 7 active infection in pediatric liver transplant patients. Pediatr Transplant. 2003;7(2):125–9.
- Michalowicz BS, Ronderos M, Camara-Silva R, Contreras A, Slots J, Human herpesviruses and Porphyromonas gingivalis are associated with juvenile periodontitis. J Periodontol. 2000;71: 981–
- Imai K, Inoue H, Tamura M, Cueno ME, Inoue H. The periodontal pathogen Porphyromonas gingivalis induces the Epstein-Barr virus lytic switch transactivator ZEBRA by histone modification. Biochimie. 94(3):839–46.
- Teughels W, Sliepen I, Quirynen M, Haake SK, Van Eldere J, Fives- Taylor P. Human cytomegalovirus enhances A. actinomycetemcomitans adherence to cells. J Dent Res, 2007;86(2):175–80.
- Sunde PT, Olsen I, Enersen M, Grinde B. Patient with severe periodontitis and subgingival Epstein-Barr virus treated with antiviral therapy. J Clin Virol. 2008;42(2):176–8.