A comprehensive randomized controlled trial investigating the effectiveness of oxygene® gel in accelerating wound healing after dental extractions

• Author Details:   
• Haydar Majeed Mahdey
• Anitha Krishnan Pandarathodiyil ^*
• Cheong Pui Jing
• Gan Lee Anne
• Chai Wei Min
• Gan Eng Sheng
• Ahmed M Daood

---

Background: Proper wound healing after dental extractions is crucial for minimizing complications and enhancing patient wellbeing. Oxygene® gel has been proposed as a potential adjuvant treatment aid to improve wound healing.

Objective: This study aimed to evaluate the effectiveness of Oxygene® gel in accelerating wound healing following tooth extractions through a comprehensive randomized controlled trial.

Materials and Methods: A split-mouth design was conducted on 27 patients who required dental extractions, with a total of 56 extraction sites at the Oral Surgery Clinic, Faculty of Dentistry, SEGi University. After extraction, participants applied Oxygene® gel to the socket site twice daily for two weeks, and wound healing was assessed on the 3rd and 14th days post-extraction using the Wound Healing Index. Statistical analysis was performed using the Wilcoxon Rank Test.

Results: The test group treated with Oxygene® Gel exhibited better wound healing compared to the control group. On the 3rd day, the mean wound healing score for the test group was 3.2963 (SD= 1.13730), while the control group had a mean score of 2.7037 (SD= 1.10296). After two weeks, the mean score for the test group increased to 4.0741 (SD= 0.78082), while the control group had a mean score of 3.5185 (SD= 0.97548).

Conclusion: Oxygene® gel demonstrated promising potential as an effective adjunctive therapy for accelerating wound healing following dental extractions. These findings support the integration of Oxygene® gel into routine post-extraction care protocols. Additional research is warranted to validate these results and explore further applications of Oxygene® gel in clinical dental practice.

Keywords:  Oxygene®gel, Extraction socket, Wound healing, Adjunctive oral wound healing aid